
| Principal Investigator | |
Dr.
Miller is co-director of the Psychobiological
Determinants of Health Laboratory. After receiving a
Ph.D. in clinical psychology at the University of
California, Los Angeles, he completed a clinical
internship at Western Psychiatric Institute & Clinic,
followed by a post-doctoral fellowship in health
psychology at Carnegie Mellon University. Dr. Miller
joined the faculty of Washington University in Saint
Louis July 2000 and after three years there, accepted
his current position at the University of British
Columbia, where he is Professor of Psychology. Dr. Miller’s research examines the biological mechanisms through which thoughts and feelings “get inside the body” to influence the development and progression of medical illnesses. More on his specific projects can be found in the research emphasis section below. This work is supported by grants from the Canadian Institutes of Health Research, the National Institute of Child Health and Human Development, the Heart and Stroke Foundation of Canada, the Human Early Learning Partnership at UBC, and the Networks of Centres of Excellence for Allergy, Genes, and Environment. Dr. Miller has received a number of honors for his research, including the Young Investigator Award from the Society of Behavioral Medicine, the Early Career Award from the American Psychosomatic Society, and the Distinguished Scientific Award for Early Career Contributions from the American Psychological Association. He is an Associate Editor at two journals, Psychological Bulletin and Psychosomatic Medicine. |
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| Research Emphasis | |
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My lab is running two major research projects over the next
few years. Biological Embedding of Early-Life SES: Mounting evidence indicates that socioeconomic status (SES) during the early years of life is an important determinant of medical outcomes in adulthood. To the extent that children spend the first years of their lives in unfavorable socioeconomic conditions, they show increased vulnerability to infectious, respiratory, coronary, and vascular diseases in adulthood. This project attempts to identify how early SES “gets inside the body” and remains there in a manner that gives rise to disease many decades later. The principle hypothesis guiding the project is that children reared in low-SES environments are often exposed to social and physical “pollutants” that shape the epigenetic landscape of the developing nervous, endocrine, and immune systems. This has long-term implications for their responsivity to stress, emotion and impulse control, immune system function, and presumably mental and physical health. We will test these ideas by doing extensive psychosocial, immunologic, and epigenetic assessments on a large sample of adults with varying SES histories. This work is being done in collaboration with my UBC colleagues Drs. Edith Chen, Michael Kobor, and Joanne Weinberg. It is funded by the National Institute Child Health and Human Development. The Psychobiology of Caregiving: Caring for a family member with a chronic illness is a demanding experience. Mounting evidence indicates that caregiving not only diminishes quality of life, but also contributes to the development and progression of various medical illnesses. This project attempts to identify the psychobiology mechanisms that are responsible for this phenomenon, and the coping strategies and personal resources which enable people to manage it most effectively. 180 adults will participate in a four-wave prospective study. 120 of them will be spousal caregivers for patients with brain cancer; the other 60 will be controls with healthy family members. Subjects will complete four data-collection sequences over one year, timed to occur after surgical recovery, at completion of radiotherapy, at completion of chemotherapy, and again two months later. The focus will be on evaluating a novel model of the psychobiology of chronic stress, which emphasizes the dynamic, cascading influence that stressors have on the endocrine, immune, and metabolic systems over time. There will also be an extensive psychosocial component focusing on the hypothesis that caregivers who can effectively self-regulate, i.e., disengage from personal goals and focus on their spouses’ illness, will show better mental and physical outcomes over the course of the follow-up. This project is supported by the Canadian Institutes of Health Research, and is being done in collaboration with Drs. Michael Kobor (UBC), Carsten Wrosch (Concordia), and Roy Ma (BC Cancer Agency). Other Studies: We are also collaborating on several other research projects, including the Canadian Healthy Infant Longitudinal Study, the Montreal Health and Aging Study, and the UBC PATHways Project. |
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| Honours and Awards | |
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2009 -
Killam Sabbatical Award, UBC |
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| Publications | |
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JOURNAL ARTICLES |
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Chen E., & Miller, G.E. (2012). "Shift-and-Persist" strategies: Why being low in socioeconomic status isn't always bad for health. Perspectives on Psychological Science, 7, 135 - 158. |
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Chen E., Miller, G.E., Lachman, M.E., Gruenewald, T.L., & Seeman, T.E. (2012). Protective factors for adults from low childhood socioeconomic circumstances: The benefits of shift-and-persist for allostatic load. Pscyhosomatic Medicine, 74, 178 - 186. |
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Miller, G. E., Lachman, M. E., Chen, E., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2011). Pathways to resilience:
Maternal nurturance as a buffer against the effects of childhood poverty on metabolic syndrome at midlife. Psychological Science,
22, 1591-1599.
Chen, E., Strunk, R. C., Trethewey, A., Schreier, H. M. C., Maharaj, N., & Miller, G. E. (2011). Resilience in low socioeconomic
status children with asthma: Adaptations to stress. Journal of Allergy and Clinical Immunology, 128, 970-976.
Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases
of aging: Moving towards a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959-997.
Chan, M., Chen, E., Hibbert, A. S., Wong, J. H. K., & Miller, G. E. (2011). Implicit measures of early-life family conditions:
Relationships to psychosocial characteristics and cardiovascular disease risk in adulthood. Health Psychology, 30, 570-578.
Ross, K., Martin, T., Chen, E., & Miller, G. E. (2011). Social encounters in daily life and two-year changes
in metabolic risk factors in young women. Development and Psychopathology, 23, 897-906.
Schreier, H. M. C., Miller, G. E., & Chen, E. (2011). Clinical potentials for measuring stress in youth with asthma. Immunology and Allergy Clinics of North America, 31, 41-54. Chen, E., Miller, G.E., Kobor, M.S., & Cole, S. (in press). Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Molecular Psychiatry Chen, E., Cohen, S., & Miller, G.E. (2010). How low socioeconomic status affects two-year hormonal trajectories in children. Psychological Science, 21, 31-37. Chen, E., Strunk, R.C., Bacharier, L.B., Chan, M., & Miller, G.E. (2010). Socioeconomic status associated with exhaled nitric oxide responses to acute stress in children with asthma. Brain, Behavior, and Immunity, 24, 444-450. Miller, G.E., & Chen, E. (2010). Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychological Science, 21, 848-856. Schaller, M., Miller, G.E., Gervais, W.M., Yager, S. & Chen, E. (2010). Mere visual perception of other people’s disease symptoms facilitates a more aggressive immune response. Psychological Science, 21, 649-652. Yager, S.S., Forlenza, M.J., & Miller, G.E. (2010). Depression and oxidative damage to lipids. Psychoneuroendocrinology, 35, 1356-1362. Chen, E., Miller, G.E., Walker, H.A., Arevalo, J.M., Sung, C.Y., & Cole, S.W. (2009). Transcriptional profiling of social class in children with asthma. Thorax, 64, 38-43. Freedland, K.E., de Geus, E.J.C., Golden, R.N., Kop, W.J., Miller, G.E., Vaccarino, V., Brumback, B., Llabre, M.M., White, V.J., & Sheps, D.S. (2009). Editorial: What’s in a name? Psychosomatic medicine and biobehavioral medicine. Psychosomatic Medicine, 71, 1-4. Heslop, C.L., Miller, G.E., & Hill, J.S. (2009). Neighbourhood socioeconomics predict non-cardiovascular death in cardiac patients. PLoS ONE, 4, e4120. Hill, M.N., Miller, G.E., Carrier, E.J., Gorzalka, B.B., & Hillard, C.J. (2009). Circulating endocannabinoids and N-acyl ethanolamides are differentially regulated by stress. Psychoneuroendocrinology, 34, 1257-1262. Marin, T.J., Chen, E., Munch, J., & Miller, G.E. (2009). Double-exposure to acute stress accentuates the impact of chronic family stress on inflammatory processes in children with asthma. Psychosomatic Medicine, 71, 378-384. Miller, G.E. (2009). In search of integrated specificity: Comment on Denson, Spanovic, and Miller (2009). Psychological Bulletin, 135, 854-856. Miller, G.E., Chen, E., & Cole., S.W. (2009). Health psychology: Developing biologically plausible models linking the social world and physical health. Annual Review of Psychology, 60, 501-524. Miller, G.E., Chen, E., Fok, A.K., Walker, H.A., Lim, A., Nicholls, E.F., Cole, S.W., & Kobor, M.S. (2009). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proceedings of the National Academy of Sciences of the United States of America, 106, 14716–14721. Miller, G.E., Gaudin, A., Zysk, E., & Chen, E. (2009). Parental support and cytokine activity in childhood asthma: The role of glucocorticoid sensitivity. Journal of Allergy and Clinical Immunology, 123, 824-830. Miller, G.E., Rohleder, N., & Cole, S.W. (2009). Chronic interpersonal stress predicts activation of pro- and anti- inflammatory signaling pathways 6 months later. Psychosomatic Medicine, 71, 57-62. Rohleder, N., Marin, T.J., Ma, R., & Miller, G.E. (2009). Biologic cost of caring for a cancer patient: Dysregulation of pro- and anti-inflammatory signaling pathways. Journal of Clinical Oncology, 27, 2909-2915. Subbarao, P., Becker, A., Brook, J.R., Daley, D., Mandhane, P.J., Miller, G.E., Turvey, S.E., & Sears, M.R. (2009). Epidemiology of asthma: Risk factors for development. Expert Review of Clinical Immunology, 5, 77-95. Wrosch, C., & Miller, G.E. (2009). Depression can be useful: Self-regulatory and emotional benefits of dysphoric mood in adolescence. Journal of Personality and Social Psychology, 96, 1181-1190. Hill, M.N., Miller, G.E., Ho, W.V., Gorzalka, B.B., & Hillard, C.J. (2008). Serum endocannabinoid content is altered in females with depressive disorders: A preliminary report. Pharmacopsychiatry, 41, 48-53. Marin, T.M., Chen, E., & Miller, G.E. (2008). Trajectories of childhood socioeconomic status and markers of cardiovascular health in adolescence. Psychosomatic Medicine, 70, 152-159. Miller, G.E., Chen, E., Sze, J., Marin, T.J., Doll, R., Ma, R., & Cole, S.W. (2008). A functional genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-ĸB signaling. Biological Psychiatry, 64, 266-272. Rohleder, N., Chen, E., Wolf, J.M., & Miller, G.E. (2008). The psychobiology of trait shame in young women: Extending the Social-Self Preservation Theory. Health Psychology, 27, 523-532. Rohleder, N. & Miller, G.E. (2008). Acute deviations from long-term trait depressive symptoms predict systemic inflammatory activity. Brain, Behavior, and Immunity, 22, 709-716. Stetler, C., & Miller, G.E. (2008). Social integration of daily activities and cortisol secretion: A laboratory based manipulation. Journal of Behavioral Medicine, 31, 249-257. Tomfohr, L., Martin, T., & Miller, G.E. (2008). Symptoms of depression and impaired endothelial functioning in healthy adolescent women. Journal of Behavioral Medicine, 31, 137-143. Wolf, J.M., Miller, G.E., & Chen, E. (2008). Parent psychological states predict changes in inflammatory markers in children with asthma and healthy children. Brain, Behavior, and Immunity, 22, 433-441. Wrosch, C., Miller, G.E., Lupien, S., & Pruessner, J.C. (2008). Diurnal cortisol secretion and 2-year changes in older adults’ acute physical symptoms: The moderating roles of negative affect and sleep. Health Psychology, 27, 685-693. Carney, R.M., Freedland, K.E, Stein, P.K., & Miller, G.E., Steinmeyer, B., Rich, M.D., & Duntley, S.P. (2007). Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease. Journal of Psychosomatic Research, 62, 463-467. Chen, E., Chim, L., Strunk, R.C., & Miller, G.E. (2007). The role of the social environment in childhood asthma. American Journal of Respiratory and Critical Care Medicine, 176, 644-649. Chen, E. & Miller, G. E. (2007). Stress and inflammation in exacerbations of asthma. Brain, Behavior, and Immunity, 21, 993-999. Cohen, S., Janicki-Deverts, D., & Miller, G.E. (2007). Psychological stress and disease. Journal of the American Medical Association, 298, 185-1687. Glassman, A.H., & Miller, G.E. (2007). Editorial: Where there is depression, there is inflammation … Sometimes! Biological Psychiatry, 62, 280-281. Marin, T.J., Martin, T.M., Blackwell, E., Stetler, C., & Miller, G.E. (2007.) Differentiating the impact of episodic and chronic stressors on HPA axis regulation in young women. Health Psychology, 26, 447-455. Miller, G. E., & Chen. E. (2007). Unfavorable socioeconomic conditions in early life presage expression of pro-inflammatory phenotype in adolescence. Psychosomatic Medicine, 69, 402-409. Miller, G.E., Chen, E., & Zhou, E.S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological Bulletin, 133, 25–45. Miller, G.E., & Wrosch, C. (2007). You’ve gotta know when to fold ‘em: Goal disengagement and systemic inflammation in adolescence. Psychological Science, 18, 773-777. Wrosch, C., Bauer, I., Miller, G.E., & Lupien, S. (2007). Regret intensity, diurnal cortisol secretion, and physical health in older individuals: Evidence for directional effects and protective factors. Psychology and Aging, 22, 319-330. Wrosch, C., Schultz, R., Miller, G.E., Lupien, S., & Dunne, E. (2007). Physical health problems, depressive mood, and cortisol secretion in old age: Buffer effects of health engagement control strategies. Health Psychology, 26, 341-349. Wrosch, C., Miller, G.E., Scheier, M.F., & Brun de Pontet, S. (2007). Giving up on unattainable goals: Benefits for health? Personality and Social Psychology Bulletin, 33, 251-265 Carney, R.M., Howells, W.B., Freedland, K.E, Duntley, S.P., Stein, P.K., Rich, M.D., & Miller, G.E. (2006). Depression and obstructive sleep apnea in patients with coronary heart disease. Psychosomatic Medicine, 68, 443-448. Chen, E., Hanson, M.D., Paterson, L.Q., Griffin, M.J., Walker, H.A., & Miller, G.E. (2006). Socioeconomic status and inflammatory processes in children with asthma: The role of psychological stress. Journal of Allergy and Clinical Immunology, 117, 1014-1020. Blackwell, E., Mendes de Leon, C., & Miller, G.E. (2006). Applying mixed regression models to the analysis of repeated-measures data in psychosomatic medicine. Psychosomatic Medicine, 68, 870-878. Forlenza, M.J., & Miller, G.E. (2006). Increased serum levels of 8-hydroxy-2’-deoxyguanosine in clinical depression. Psychosomatic Medicine, 68, 1-7. Freedland, K.E., Miller, G.E., & Sheps, D.S. (2006). Editorial: The great debate, revisited. Psychosomatic Medicine, 68, 179-184. Miller, G.E., & Chen, E. (2006). Stressful experience and diminished expression of genes encoding the glucocorticoid receptor and b2-adrenergic receptor in children with asthma. Proceedings of the National Academy of Sciences of the United States of America, 103, 5496-5501. Miller, G.E., & Blackwell, E. (2006). Turning up the heat: Inflammation as a mechanism linking chronic stress, depression, and heart disease. Current Directions in Psychological Science, 15, 269-272. Stetler, C.A., Chen, E., & Miller, G.E. (2006) Written disclosure of experiences with racial discrimination and antibody response to an influenza vaccine. International Journal of Behavioral Medicine, 13, 60-68. Miller, G.E., Freedland, K.E., & Carney, R.M. (2005) Depressive symptoms and the regulation of pro-inflammatory cytokine expression in patients with coronary heart disease. Journal of Psychosomatic Research, 59, 231-236 Miller, G.E., Freedland, K.E., Duntley, S., & Carney, R.M. (2005). Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromes. The American Journal of Cardiology. 95, 317-321. Miller, G.E., Rohleder, N., Stetler, C.A., & Kirschbaum, C. (2005) Clinical depression and regulation of the inflammatory response during acute stress. Psychosomatic Medicine, 67, 679-687. Pressman, S., Cohen, S., Miller, G. E., Rabin, B. S., Barker, A., & Treanor, J. (2005). Loneliness, social network size, and immune response to influenza vaccination in college freshman.Health Psychology, 24, 297-306. Stetler, C.A., & Miller, G.E. (2005). Blunted cortisol response to awakening in mild to moderate depression: Regulatory influences of sleep patterns and social contacts. Journal of Abnormal Psychology, 114, 697-705. Martire, L., Lustig, A., Schultz, R.M., Miller, G.E., & Helgeson, V.E. (2004). Is it beneficial to involve a family member? A meta-analysis of psychosocial interventions for chronic illness. Health Psychology. 6, 599-611. Miller, G.E., Cohen S., Pressman S., Barkin A., Rabin, B.S., & Treanor, J. (2004). Psychological stress and antibody response to influenza vaccination. When is the critical period for stress, and how does it get inside the body? Psychosomatic Medicine, 66, 215-223. Segerstrom, S.C., & Miller, G.E. (2004). Stress and the human immune system: A meta-analytic review of 30 years of inquiry. Psychological Bulletin¸130, 601-630.sycholo Miller, G.E., Freedland, K.E., Carney, R.M., Stetler, C.A., & Banks, W.A. (2003). Cynical hostility, depressive symptoms, and the expression of inflammatory risk markers for coronary heart disease. Journal of Behavioral Medicine, 26, 501-515. Miller, G.E., Freedland, K.E., Carney, R.M., Stetler, C.A., & Banks, W.A. (2003). Pathways linking depression, adiposity, and inflammation in healthy young adults. Brain, Behavior, and Immunity, 17, 276-285. Wrosch, C., Scheier, M.F., Miller, G.E., Carver, C.S., & Schultz, R. (2003). Adaptive self-regulation of unattainable goals: Goal disengagement, goal re-engagement, and subjective well-being. Personality and Social Psychology Bulletin, 29, 1494-1508. Carney, R.M., Freedland, K.E., Miller, G.E., & Jaffe, A.S. (2002). Depression as a risk factor for cardiac mortality and morbidity: A review of potential mechanisms. Journal of Psychosomatic Research, 53, 897-902. Miller, G.E., Cohen, S., & Ritchey, A.K. (2002). Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid resistance model. Health Psychology, 21, 531-541. Miller, G.E., Stetler, C.A., Carney, R.M., Freedland, K.E., & Banks, W.A. (2002). Clinical depression and inflammatory risk markers for coronary heart disease. American Journal of Cardiology, 90, 1279-1283. Cohen, S., Miller, G.E., & Rabin, B.S. (2001). Psychological stress and antibody response to immunization: A critical review of the human literature. Psychsomatic Medicine, 63, 7-18. Miller, G.E., & Cohen, S. (2001). Psychological interventions and the immune system: A meta-analytic review and critique. Health Psychology, 20, 47-63. Miller, G.E., & Cohen, S. (2001). Psychological interventions and the immune system: A meta-analytic review and critique. Abstract/Commentary in Evidence Based Mental Health, 4, 83. Dopp, J.M., Miller, G.E., Myers, H.F., & Fahey, J.L. (2000). Increased natural killer cell mobilization and cytotoxicity during marital conflict. Brain, Behavior, and Immunity, 14, 10-26. Miller, G.E., Cohen, S., & Herbert, T.B. (1999). Pathways linking major depression and immunity in ambulatory female patients. Psychosomatic Medicine, 61, 850-860. Miller, G.E., Cohen, S., Rabin. B.S., Doyle, W.J., & Skoner, D. (1999). Personality and tonic cardiovascular, neuroendocrine, and immune parameters. Brain, Behavior, and Immunity, 13, 109-123. Miller, G.E., Dopp, J.M., Myers, H.F., Stevens, S.Y., & Fahey, J.L. (1999). Psychosocial predictors of natural killer cell mobilization during marital conflict. Health Psychology, 18, 262-271. Benschop, R.J., Green, R., Mills, P.J., Naliboff, B.D., Cacioppo, J.T., Herbert, T.B., van der Pompe, G., Miller, G.E., Matthews, K.A., Godaert, G.L.R., Glaser, R., Manuck, S.B., Heijnen, C.J., Dopp, J.M., Bijlsma, J., Kiecolt-Glaser, J.K., Rabin, B.S., & Cohen, S. (1998). Cardiovascular and immune responses to acute psychological stress in young and old women: A meta-investigation. Psychosomatic Medicine, 60, 290-296. Miller, G.E., & Cole, S.W. (1998). Social relationships and the progression of human immunodeficiency virus infection: A review of evidence and possible underlying mechanisms. Annals of Behavioral Medicine, 20, 181-189. Miller, G.E., & Bradbury, T.N. (1995). Refining the association between attributions and behavior in marital interaction. Journal of Family Psychology, 9, 196-208. Miller, G.E., Jarvik, M.E., Caskey, N.H., Segerstrom, S.C., Rosenblatt, M.R., McCarthy, W.J. (1994). Cigarette mentholation increases smokers' exhaled carbon monoxide levels. Experimental and Clinical Psychopharmacology, 2, 154-160. EDITED BOOKS Miller, G.E. & Chen, E. (Eds.). (2005). Current Directions in Health Psychology. New York, NY: Prentice Hall. BOOK CHAPTERS Chen, E., & Miller, G.E. (in press). Social context as an individual difference in PNI. In R. Ader, D. Felten, & N. Cohen (Eds.) Psychoneuroimmunology, 4th edition. New York: Academic Press. McDermott, K.B., & Miller, G.E. (in press). Designing studies to avoid confounds. In R. Sternberg, H.L. Roediger, & D. Halpern. (Eds.) Critical thinking in psychology. Cambridge, England: Cambridge University Press. Miller, G.E. (in press). How does stress get inside the body to influence depression? Some answers from the perspective of behavioral immunology. In D.M. Barch (Ed.) Cognitive and affective neuroscience approaches to psychopathology. New York, NY: Oxford University Press. Miller, G.E., & Cohen, S. (in press). Infectious disease and psychoneuroimmunology. In K. Vedhara & M. Irwin (Eds.) Human psychoneuroimmunology. New York, NY: Oxford University Press. Stetler, C.A., Murali, R., Chen, E., & Miller, G.E. (2005). Stress, immunity, and disease. In C.L. Cooper (Ed.) Handbook of stress medicine and health (pp. 131-154), London: CRC Press. Cohen, S., & Miller, G.E. (2001). Stress, immunity, and infectious disease. In R. Ader, D. Felten, & N. Cohen (Eds.) Psychoneuroimmunology, 3rd edition (pp. 499-509). New York: Academic Press. Kemeny, M.E., & Miller, G.E. (1999). Effects of psychosocial interventions on immune functions. In M. Schedlowski & U. Tewes (Eds.) Psychoneuroimmunology: An interdisciplinary introduction. (pp. 373-415), New York: Plenum Press.
Science "The Seductive Allure of Behavioral Epigenetics" July 2010 The Economist "The Evolutionary Origin of Depression: Mild and Bitter" July 2009 New York Times Annual Magazine "Year in Ideas" which outlines "70 of the Ideas that helped make 2007 what it was" "O, the Oprah Magazine" in the January 2008 Issue
Scientific American Mind
"Who Said Quitters Never
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